SINCE World War II, medical science has progressed into a stage where competitive medications are around for treat precisely the same ailment in several people. This is not almost brands (that is a trade issue) but generic drugs (that is a scientific issue). Within this report, we shall consider the various factors that decide selecting a certain drug.

Safety: The next sub-criteria should be considered within the criterion of safety:

* Acute therapeutic index: In the event the patient’s condition is acute, how effective can be a particular drug regardless of whether it has certain side-effects so long as the acuteness with the condition is lowered? Example: narcotic pain-killers work well in healing pain but have the opportunity side-effect of addiction.

* Long-term safety: medicine could possibly be safe in short-term treatment, but exactly how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in case there is prolonged use.

* Drug-drug interaction risk: Medicine is chemicals, and several chemicals react to create a different chemical, which has an effect that will harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.

Drug-drug interaction risk is of two types:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, independent of the other, have certain effects on one or maybe more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends upon due to the metabolism. This causes more the side-effects of Lexapro.

· Pharmacodynamic: Here, a couple of drugs actually produce the same relation to precisely the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of both the drugs are more serious.

Tolerability: A drug could possibly be effective and not tolerable by all patients. Example: Allergies to specific drugs in certain people. Short-term and long-term tolerability need to be taken into account. Efficacy: A drug isn’t equally efficient at all patients. For example, some patients with depression or anxiety attacks experience respite from escitalopram, but there are several who don’t, who therefore need to be prescribed some other anti-depressant. The rate of start of therapeutic action is a vital step to be regarded as too.

Cost: Cost does not mean the cost of buying some medicine alone. It ought to also cover the cost of treatment of a complication that will arise by using some other drug. Example: Inside a individual who insists on taking alcohol but has to be treated for depression is often administered an SSRI drug since these drugs don’t potentiate the consequences of alcohol, whereas another band of anti-depressants (including tricyclics) could cause a new problem in such patients, which will demand a various and expensive treatment. Therefore, it’s better to prescribe the more expensive escitalopram instead of a cheaper tricyclic in such patients.

Simple treatment: The simplest mode of administration is preferred. When there is a choice between a shot and oral administration, aforementioned is preferred if the efficacy of both the modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are an important factor to choose simple treatment.
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