SINCE The second world war, medical science has progressed with a stage where competitive medications are available to treat the same ailment in numerous people. It’s not pretty much brands (that is a trade issue) but generic drugs (that is a scientific issue). In this report, we shall glance at the various factors that decide picking a a particular drug.

Safety: The following sub-criteria should be considered within the criterion of safety:

* Acute therapeutic index: If your patient’s condition is acute, how effective can be a particular drug even if they have certain side-effects as long as the acuteness from the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but come with the possible side-effect of addiction.

* Long-term safety: drug directory may be safe in short-term treatment, but wait, how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in the event of prolonged use.

* Drug-drug interaction risk: Medicine is chemicals, and several chemicals answer create a different chemical, that have an effect that could harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to make a new condition that warrants separate treatment.

Drug-drug interaction risk is of two kinds:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from the other, have certain effects on a single or maybe more body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends upon for the metabolism. This makes more the side-effects of Lexapro.

· Pharmacodynamic: Here, two or more drugs actually create the same influence on the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of both the drugs are more serious.

Tolerability: A drug may be effective and not tolerable by all patients. Example: Allergies to specific drugs in some people. Short-term and long-term tolerability have to be taken into account. Efficacy: A drug is just not equally effective in all patients. For example, some patients with depression or anxiety disorders experience relief from escitalopram, but there are numerous that don’t, who therefore have to be prescribed some other anti-depressant. The interest rate of beginning of therapeutic action is a the answer to be regarded as too.

Cost: Cost does not necessarily mean the cost of acquisition of a particular medicine alone. It must also cover the cost of treatment of a complication that could arise from utilizing some other drug. Example: Inside a one who insists on taking alcohol but should be treated for depression is generally administered an SSRI drug as these drugs don’t potentiate the effects of alcohol, whereas another gang of anti-depressants (like tricyclics) can cause a new condition in such patients, which may have to have a different and expensive treatment. Therefore, it’s preferable to prescribe the more costly escitalopram instead of a cheaper tricyclic in these patients.

Simple treatment: The simplest mode of administration is preferred. If there is an alternative between a shot and oral administration, the latter is preferred if your efficacy of both the modes is comparable. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are a key factor to choose simple treatment.
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