SINCE The second world war, medical science has progressed with a stage where competitive medications are available to treat the identical ailment in different people. This isn’t almost brands (which is a trade issue) but generic drugs (which is a scientific issue). With this report, we shall consider the various factors that decide the selection of a specific drug.

Safety: The subsequent sub-criteria should be considered beneath the criterion of safety:

* Acute therapeutic index: If the patient’s condition is acute, how effective can be a particular drug even though it’s certain side-effects so long as the acuteness in the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but include the opportunity side-effect of addiction.

* Long-term safety: medicine might be safe in short-term treatment, but wait, how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in case of prolonged use.

* Drug-drug interaction risk: Medicines are chemicals, and lots of chemicals reply to develop a different chemical, which has an effect that could harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.

Drug-drug interaction risk is of two kinds:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of each other, have certain effects using one or more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends on because of its metabolism. This makes an increase in the side-effects of Lexapro.

· Pharmacodynamic: Here, 2 or more drugs actually make the same effect on the identical organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of the medicines are more serious.

Tolerability: A medication might be effective but not tolerable by all patients. Example: Allergies to a particular drugs in most people. Short-term and long-term tolerability should be taken into account. Efficacy: A medication isn’t equally effective in all patients. For example, some patients with depression or panic disorders experience respite from escitalopram, but there are several that don’t, who therefore should be prescribed a different anti-depressant. The speed of onset of therapeutic action is an important key to be regarded as too.

Cost: Cost does not necessarily mean the price tag on acquiring some medicine alone. It must also cover the price tag on treatments for a complication that could arise while using a different drug. Example: Within a one who insists on taking alcohol and yet must be treated for depression is usually administered an SSRI drug because they drugs don’t potentiate the results of alcohol, whereas another number of anti-depressants (for example tricyclics) can cause a whole new symptom in such patients, which could require a various and expensive treatment. Therefore, it’s preferable to prescribe the more expensive escitalopram as opposed to a cheaper tricyclic in such patients.

Simplicity of treatment: The simplest mode of administration is preferred. If there is a choice between a shot and oral administration, the latter is preferred when the efficacy of the modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are key point to choose simple treatment.
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