SINCE World war 2, medical science has progressed to a stage where competitive medications are available to treat the same ailment in numerous people. This is not just about brands (that is a trade issue) but generic drugs (that is a scientific issue). On this report, we shall glance at the various factors that decide selecting a specific drug.

Safety: The subsequent sub-criteria should be considered within the criterion of safety:

* Acute therapeutic index: If your patient’s condition is acute, how effective is often a particular drug even though it’s certain side-effects so long as the acuteness of the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but have the potential side-effect of addiction.

* Long-term safety: medicine could possibly be safe in short-term treatment, but wait, how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the case of prolonged use.

* Drug-drug interaction risk: Prescription medication is chemicals, and lots of chemicals react to create a different chemical, that have an effect that could harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.

Drug-drug interaction risk is of two sorts:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from each other, have certain effects one or even more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is dependent upon due to the metabolism. This causes a rise in the side-effects of Lexapro.

· Pharmacodynamic: Here, two or more drugs actually create the same effect on the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of both medicines are more intense.

Tolerability: A drug could possibly be effective although not tolerable by all patients. Example: Allergies to specific drugs in certain people. Short-term and long-term tolerability have to be considered. Efficacy: A drug just isn’t equally effective in all patients. By way of example, some patients with depression or anxiety disorders experience relief from escitalopram, but there are numerous who don’t, who therefore have to be prescribed some other anti-depressant. The rate of onset of therapeutic action is a crucial key to be regarded too.

Cost: Cost doesn’t imply the cost of purchase of some medicine alone. It ought to also cover the cost of treating a complication that could arise while using some other drug. Example: In a one who insists on taking alcohol but needs to be treated for depression is often administered an SSRI drug because they drugs don’t potentiate the results of alcohol, whereas another number of anti-depressants (like tricyclics) could cause a whole new condition in such patients, which would require a different and expensive treatment. Therefore, it’s safer to prescribe the more expensive escitalopram as opposed to a cheaper tricyclic in this patients.

Simplicity of treatment: Most effective mode of administration is preferred. If you find a choice between an injection and oral administration, aforementioned is preferred when the efficacy of both modes is analogous. Or, local application is chosen over the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are a key factor to decide simplicity of treatment.
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