SINCE World war 2, medical science has progressed to a stage where competitive medications are for sale to treat precisely the same ailment in several people. This is simply not almost brands (the trade issue) but generic drugs (the scientific issue). Within this report, we shall go through the various factors that decide selecting a particular drug.

Safety: The following sub-criteria have to be considered beneath the criterion of safety:

* Acute therapeutic index: If the patient’s condition is acute, how effective is often a particular drug even if it’s certain side-effects as long as the acuteness in the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but have the opportunity side-effect of addiction.

* Long-term safety: drug could possibly be safe in short-term treatment, but exactly how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in case of prolonged use.

* Drug-drug interaction risk: Medicines are chemicals, and lots of chemicals respond to produce a different chemical, which has an effect which could harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.

Drug-drug interaction risk is of 2 types:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of the other, have certain effects using one or more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is dependent upon because of its metabolism. This makes an increase in the side-effects of Lexapro.

· Pharmacodynamic: Here, several drugs actually make the same relation to precisely the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of the two drugs are more intense.

Tolerability: A drug could possibly be effective and not tolerable by all patients. Example: Allergies to particular drugs in certain people. Short-term and long-term tolerability need to be taken into consideration. Efficacy: A drug isn’t equally efficient at all patients. As an example, some patients with depression or anxiety attacks experience respite from escitalopram, but there are lots of who don’t, who therefore need to be prescribed a different anti-depressant. The interest rate of beginning of therapeutic action is an important factor to be considered too.

Cost: Cost does not always mean the price of acquiring a particular medicine alone. It must also cover the price of treatments for a complication which could arise from utilizing a different drug. Example: Within a individual that insists on taking alcohol yet has to be treated for depression is often administered an SSRI drug since these drugs don’t potentiate the results of alcohol, whereas another band of anti-depressants (like tricyclics) might cause a fresh overuse injury in such patients, which may demand a different and expensive treatment. Therefore, it’s preferable to prescribe the more costly escitalopram instead of a cheaper tricyclic such patients.

Simplicity of treatment: The best mode of administration is preferred. If there is a choice between a shot and oral administration, rogues is preferred in the event the efficacy of the two modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are key point to make a decision simplicity of treatment.
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