SINCE World war 2, medical science has progressed to a stage where competitive medications are for sale to treat the identical ailment in several people. It’s not almost brands (which is a trade issue) but generic drugs (which is a scientific issue). Within this report, we shall look at the various factors that decide selecting a specific drug.

Safety: The subsequent sub-criteria must be considered under the criterion of safety:

* Acute therapeutic index: In the event the patient’s condition is acute, how effective is often a particular drug even though it’s certain side-effects as long as the acuteness of the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but have the potential side-effect of addiction.

* Long-term safety: medication directory could be safe in short-term treatment, but how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the event of prolonged use.

* Drug-drug interaction risk: Drugs are chemicals, and lots of chemicals answer produce a different chemical, that have an effect that could harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.

Drug-drug interaction risk is of two types:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of the other person, have certain effects one or more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends upon for the metabolism. This causes a rise in the side-effects of Lexapro.

· Pharmacodynamic: Here, several drugs actually create the same influence on the identical organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of the prescription medication is more intense.

Tolerability: A medication could be effective but not tolerable by all patients. Example: Allergies to specific drugs in a few people. Short-term and long-term tolerability need to be taken into consideration. Efficacy: A medication is not equally effective in all patients. By way of example, some patients with depression or anxiety disorders experience respite from escitalopram, but there are lots of that don’t, who therefore need to be prescribed some other anti-depressant. The rate of onset of therapeutic action is an important step to be regarded too.

Cost: Cost doesn’t imply the price tag on buying some medicine alone. It should also cover the price tag on management of a complication that could arise from using some other drug. Example: In the one who insists on taking alcohol and yet must be treated for depression is often administered an SSRI drug because these drugs don’t potentiate the end results of alcohol, whereas another band of anti-depressants (including tricyclics) can cause a new condition in such patients, which would require a various and expensive treatment. Therefore, it’s preferable to prescribe the more expensive escitalopram rather than cheaper tricyclic in these patients.

Simple treatment: The simplest mode of administration is preferred. If you have an alternative between a shot and oral administration, the latter is preferred when the efficacy of the modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are key point to choose simple treatment.
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