SINCE World War II, medical science has progressed with a stage where competitive medications are for sale to treat the same ailment in numerous people. This isn’t pretty much brands (the industry trade issue) but generic drugs (the industry scientific issue). On this report, we shall look at the various factors that decide the selection of a selected drug.

Safety: The subsequent sub-criteria should be considered within the criterion of safety:

* Acute therapeutic index: In the event the patient’s condition is acute, how effective is really a particular drug even though they have certain side-effects so long as the acuteness in the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but include the possibility side-effect of addiction.

* Long-term safety: drug might be safe in short-term treatment, so how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in case there is prolonged use.

* Drug-drug interaction risk: Medicine is chemicals, and several chemicals answer make a different chemical, that have an effect that may harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.

Drug-drug interaction risk is of two kinds:

· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of each other, have certain effects one or even more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is determined by for the metabolism. This will cause a rise in the side-effects of Lexapro.

· Pharmacodynamic: Here, 2 or more drugs actually generate the same relation to the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects such as drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of both the medicines are more serious.

Tolerability: A medicine might be effective although not tolerable by all patients. Example: Allergies to specific drugs in most people. Short-term and long-term tolerability need to be taken into consideration. Efficacy: A medicine isn’t equally efficient at all patients. By way of example, some patients with depression or anxiety attacks experience reduced escitalopram, but there are numerous that do not, who therefore need to be prescribed some other anti-depressant. The rate of start of therapeutic action is a factor to be looked at too.

Cost: Cost doesn’t imply the expense of buying some medicine alone. It ought to also cover the expense of management of a complication that may arise from utilizing some other drug. Example: Within a one who insists on taking alcohol but has to be treated for depression is generally administered an SSRI drug as these drugs don’t potentiate the results of alcohol, whereas another number of anti-depressants (such as tricyclics) might cause a fresh problem in such patients, which would have to have a different and expensive treatment. Therefore, it’s better to prescribe the more expensive escitalopram instead of a cheaper tricyclic in this patients.

Simplicity of treatment: The best mode of administration is preferred. When there is an alternative between a shot and oral administration, aforementioned is preferred when the efficacy of both the modes can be compared. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key factor to make a decision simplicity of treatment.
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