SINCE Wwii, medical science has progressed with a stage where competitive medications are for sale to treat precisely the same ailment in several people. This is simply not just about brands (that is a trade issue) but generic drugs (that is a scientific issue). In this report, we shall consider the various factors that decide selecting a particular drug.

Safety: These sub-criteria has to be considered beneath the criterion of safety:

* Acute therapeutic index: When the patient’s condition is acute, how effective is really a particular drug regardless of whether it’s got certain side-effects so long as the acuteness from the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but come with the possible side-effect of addiction.

* Long-term safety: medicationdirectory.com may be safe in short-term treatment, but wait, how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the case of prolonged use.

* Drug-drug interaction risk: Medicine is chemicals, and lots of chemicals reply to create a different chemical, which has an effect that could harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.

Drug-drug interaction risk is of two types:

· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of each other, have certain effects on one or higher body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends on for the metabolism. This makes an increase in the side-effects of Lexapro.

· Pharmacodynamic: Here, two or more drugs actually generate the same impact on precisely the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of both medicines are more intense.

Tolerability: A drug may be effective and not tolerable by all patients. Example: Allergies to specific drugs in certain people. Short-term and long-term tolerability must be considered. Efficacy: A drug just isn’t equally great at all patients. By way of example, some patients with depression or anxiety disorders experience relief from escitalopram, but there are many that do not, who therefore must be prescribed another anti-depressant. The speed of onset of therapeutic action is a crucial step to be considered too.

Cost: Cost does not mean the expense of acquisition of a specific medicine alone. It must also cover the expense of treating a complication that could arise while using another drug. Example: Inside a individual that insists on taking alcohol but must be treated for depression is generally administered an SSRI drug because these drugs don’t potentiate the results of alcohol, whereas another group of anti-depressants (for example tricyclics) could cause a new condition in such patients, which may need a different and expensive treatment. Therefore, it’s better to prescribe the more expensive escitalopram instead of a cheaper tricyclic such patients.

Simplicity of treatment: The simplest mode of administration is preferred. If you have an option between a shot and oral administration, aforementioned is preferred in the event the efficacy of both modes is the identical. Or, local application is preferred to the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are a key factor to make a decision simple treatment.
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